Tetrahydronaphthalene and indane compounds useful for reversing

Details Tetrahydronaphthalene and indane compounds useful for reversing Tetrahydronaphthalene and indane compounds useful for reversing

1990-05-08

1991-10-29

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Sulfur, selenium or tellurium compound

514530, 514532, 514608, 514678, 514709, 514725, A61K 3110

Patent

active

050617338

ABSTRACT:
The use of compounds of formula I as topical agents to combat the disorders of the skin produced by photodamage which disorders include: wrinklin, elastosis and premature aging is described. Compounds of formula I are ##STR1## wherein n represents 1 or 2, Z represents --S(O)R, wherein R represents lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkoxy-lower-alkyl, lower-alkanoyl-lower-alkyl, hydroxy-lower-alkyl, halo-lower-alkyl, lower-carbalkoxy-lower-alkyl, lower-alkoxy, hydroxy, mono-lower-alkyl amino or di-lower-alkylamino
and pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 4608146 (1986-07-01), Kligman
patent: 4877805 (1989-10-01), Kligman
patent: 4888342 (1989-12-01), Kligman

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