Tetrahydroisoquinoline-type renin inhibiting peptides

Details Tetrahydroisoquinoline-type renin inhibiting peptides Tetrahydroisoquinoline-type renin inhibiting peptides

1991-03-05

1993-06-15

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514 18, 514 19, 514913, 514885, 544128, A61K 31535, A61K 3700, C07D41300

Patent

active

052198510

ABSTRACT:
The invention concerns novel renin-inhibitory compounds which contain a tetrahydroisoquinoline or similar heterocycle at the P.sub.3 position. These are useful for treating hypertension, congestive heart failure, glaucoma, hyperaldosteronism, and diseases caused by retroviruses including HTLV-I, -II and -III. Processes for preparing the compounds, compositions containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension, or hyperaldosteronism.

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Huber et al., J. Cardiovascular Pharmacology, 1987, 10 (Suppl. 7), pp. 554-558.

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