Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-06-25
1987-05-19
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61U 3147
Patent
active
046669183
ABSTRACT:
The invention relates to tetrahydroisoquinoline derivatives of the Formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each selected from the group consisting of a hydrogen and a hydroxyl group. These derivatives are useful in tocology (obstetrics).
Administration of the inventive compounds induces relaxation of uterine muscles, a property that is particularly useful in cases of second trimester miscarriage, premature birth up to the 37th or 38th week of pregnancy, and during delivery. The compounds are especially useful from the onset of labor up to delivery of the newborn's head, a period which is often accompanied or complicated by frequent, violent, uncoordinated contractions of the uterus. The compounds are also useful in obstetric and gynecological operations, such as a hysterectomy, surgery for acute placental insufficiency, etc.
REFERENCES:
The Action of Sympathicomimetic Drugs on Uterine Muscle, P. K. Kloeck.
The Action of Betamimetrics on the Myometrium, R. Czekanowski.
The Administration of Beta-Sympathomimetic Agents in Obstretric Emergencies.
Current Status of Tocolysis Labor Inhibition; Hans Weidinger.
Triquinol, Experimental & Chemical Studies, Clinical Tests-Pharmachim. Bul.
Bulletin of the Institute of Physiology; vol. IX (1965).
Dryanska Margarita D.
Ivanov Chavdar B.
Ivanova Nedyalka S.
Nikolova Milka P.
Zabunova Orhideya B.
Friedman Stanley J.
TPO "Pharmachim"
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