Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1979-11-08
1981-03-17
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
546146, 546147, C07D21716, A61K 3147
Patent
active
042567513
ABSTRACT:
A compound of the formula: ##STR1## wherein R.sup.1 is hydrogen or methyl, is prepared by condensing a compound of the formula: ##STR2## wherein R.sup.2 is alkyl, aryl or aralkyl and R.sup.1 is same as above, or a reactive derivative thereof with 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid or an ester thereof to give a compound of the formula: ##STR3## wherein R.sup.3 is an ester residue and R.sup.1 and R.sup.2 are same as above, followed by hydrolysis or ammonolysis of said compound (IV). The compound (I) is useful as a diagnostic or therapeutic agent for angiotensin-related hypertension.
REFERENCES:
patent: 4046889 (1977-09-01), Ondetti et al.
Mita et al., "Chem. Pharm. Bull.," vol. 26(4), 1978, pp. 1333-1335.
Hayashi Kimiaki
Kato Jyoji
Uchida Tomofumi
Yoneda Naoto
Daus Donald G.
Tanabe Seiyaku Co. Ltd.
Turnipseed James H.
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