Tetrahydroisoquinoline basic ethers and pharmaceutical compositi

Details Tetrahydroisoquinoline basic ethers and pharmaceutical compositi Tetrahydroisoquinoline basic ethers and pharmaceutical compositi

1976-08-02

1978-09-12

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260287D, 260288D, 260283SA, 260289D, C07D21716, A61K 3147

Patent

active

041138694

ABSTRACT:
Compounds of the formula (II): ##STR1## and salts thereof wherein R.sub.1 is a C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl phenyl, naphthyl, aralkyl, substituted phenyl or substituted naphthyl group; R.sub.2 is a group: ##STR2## wherein R.sub.6 is a hydrogen atom or a C.sub.1-6 alkyl group, R.sub.7 is a hydrogen atom or a C.sub.1-6 alkyl, phenyl, tolyl, or benzyl group or R.sub.6 is linked to R.sub.7 so that the NR.sub.6 R.sub.7 moiety is a 5-,6- or 7- membered ring, R.sub.8 is a hydrogen atom or a C.sub.1-4 alkyl group or is joined to R.sub.6 to form part of a morpholino ring and R.sub.9 and R.sub.10 are each hydrogen atoms or C.sub.1-4 alkyl groups; R.sub.3 is a hydrogen atom or a C.sub.1-6 alkyl or a trifluoromethyl group; R.sub.4 is a hydrogen atom or a C.sub.1-6 alkyl, benzyl or phenyl group or an acyl group containing from 2 to 7 carbon atoms and R.sub.5 is a hydrogen atom or a -C.sub.1-6 alkyl group; have been found to be mood modifying agents and anorexia agents.

REFERENCES:
patent: 3479358 (1969-11-01), Hansen et al.
patent: 3666763 (1972-05-01), Grethe et al.
patent: 3855227 (1974-12-01), Hollander et al.
patent: 3870722 (1975-03-01), Houlihan et al.
patent: 3872125 (1975-03-01), Houlihan et al.
patent: 3878215 (1975-04-01), Houlihan et al.
patent: 3910924 (1975-10-01), Tamura et al.
patent: 3947456 (1976-03-01), Rheiner
patent: 3953456 (1976-04-01), Nakagawa et al.
patent: 4013663 (1977-03-01), Westermann et al.

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