Tetrahydroisoquino(2,1-C)(1,3)benzodiazepines

Details Tetrahydroisoquino(2,1-C)(1,3)benzodiazepines Tetrahydroisoquino(2,1-C)(1,3)benzodiazepines

1989-04-28

1990-03-13

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540555, C07D45300, A61K 3155

Patent

active

049083619

ABSTRACT:
Novel Tetrahydroisoquino[2,1-c][1,3]benzodiazepines are disclosed having the formula ##STR1## where X and Y are each independently hydrogen, halogen, loweralkyl, loweralkoxy or --CF.sub.3, and R is hydrogen or loweralkyl, and the pharmaceutically acceptable acid addition salts thereof and where applicable the geometric and optical isomers and racemic mixtures thereof. The compounds of this invention display utility in enhancing memory.

REFERENCES:
patent: 3435038 (1969-03-01), Hardtmann
patent: 4309424 (1982-01-01), Martin et al.
patent: 4459230 (1984-07-01), Martin et al.
patent: 4459231 (1984-07-01), Martin et al.
Geyer et al., J. Med. Chem., 25, 340-346 (1982).
Setescak et al., J. Med. Chem., 27, 401-404 (1984).
Martin et al., J. Heterocyclic Chem., 22, 1105-1107 (1985).

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