Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2008-06-17
2008-06-17
Seaman, D. Margaret (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
07388101
ABSTRACT:
The present invention relates to a tetrahydrofuran compound having cis substituents, the derivatives thereof and a process for preparing the same, and in particular relates to a dihydrofuran-3-ylidene triflate compound having cis substituents at C2and C5positions prepared through Prins-type cyclization using a homopropargylic alcohol derivative as a starting material in the presence of Lewis acid catalyst, a tetrahydrofuran compound having cis substituents at C2, C3and C5positions prepared through the hydrolysis of triflate group in the derivatives of the dihydrofuran-3-ylidene triflate compound, and a preparation method thereof.The derivatives and the target tetrahydrofuran compound prepared according to the present invention are hydrofuran compounds with novel structures having cis substituents at C2, C3and/or C5positions, which are useful as a derivative for synthesizing drugs such as an antagonist for neurokinin receptor.
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Cha Joo Hwan
Chavre Satish N.
Cho Yong Seo
Choi Kyung Il
Choo Hyunah
Chandrakumar Nizal S
Frommer & Lawrence & Haug LLP
Korea Institute of Science and Technology
Santucci Ronald R.
Seaman D. Margaret
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