Tetrahydrofuran derivatives and their use as NK-1 antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C549S475000

Reexamination Certificate

active

06964981

ABSTRACT:
The present invention relates compounds that are NK-1 antagonists and that are of use in the treatment or prevention of depression, anxiety, pain, inflammation, migaine, emesis or postherpetic neuralgia.

REFERENCES:
patent: 5750549 (1998-05-01), Caldwell et al.
Honoo Satake et al, Zoological Science, 20: 533-549, 2003.
Reichard, G. A. Et Al: “The design and synthesis of novel NK1/NK2 dual antagonists”, Bioorganic & Medicinal Chemistry Letters, vol. 10, No. 20, Oct. 16, 2000, pp. 2329-2332.

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