Tetrahydrofuran-containing macrocyclic polyether carboxylic acid

Details Tetrahydrofuran-containing macrocyclic polyether carboxylic acid Tetrahydrofuran-containing macrocyclic polyether carboxylic acid

1989-08-14

1990-06-19

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549349, 549351, A61K 31335, C07D32300

Patent

active

049354426

ABSTRACT:
A series of tetrahydrofuran-containing, macrocyclic polyether compounds. The macrocycles have a 21-membered ring, incorporating six oxygen atoms, and they have a carboxy group (or a salt thereof) directed towards the interior of the ring. Administration of the compounds of the invention to ruminant animals (e.g. cattle and sheep) modifies their digestive fermentation processes such that the volatile fatty acids produced in the rumen contain a higher proportion of propionates rather than acetates, thereby increasing the efficiency of feed utilization in said ruminant animals. Additionally, the compounds of the invention show antibacterial activity in vitro against certain gram-positive microorganisms.

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