Tetrahydrofuran compounds and analogs thereof

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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424267, 544312, 546 20, 546199, 549497, 549504, A61K 31505, A61K 31445, C07D40514

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active

044142161

ABSTRACT:
There are disclosed tetrahydrofuran compounds and analogs thereof of the formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein X is oxygen or sulfur, R.sup.1 and R.sup.2 are each hydrogen, halogen, lower alkyl or lower alkoxy, and Am is a group of the formula: ##STR2## wherein Z is oxygen or sulfur, R.sup.3 is hydrogen or halogen, R.sup.4 is hydrogen, lower alkyl or phenyl which may be substituted by 1 to 3 substituents at any position(s) on the phenyl nucleus, each substituent being independently selected from halogen, lower alkyl and lower alkoxy, and R.sup.5 is hydrogen or lower alkyl. Such compounds are useful as neuroleptics.

REFERENCES:
patent: 3845060 (1974-10-01), Huebner
patent: 4148796 (1979-04-01), Yamamoto et al.
patent: 4264613 (1981-04-01), Regnier et al.
patent: 4329353 (1982-05-01), Stokbroeky et al.

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