Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1995-06-02
1997-12-02
Bernhardt, Emily
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
5142278, 5142362, 514252, 544 60, 544121, 544337, 544357, 544364, 544366, 548112, 5482686, 5482688, 549559, 560254, 562840, A61K 31495, C07D40514, C07D41314, C07F 96518
Patent
active
056936265
ABSTRACT:
A compound represented by the formula I ##STR1## wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R.sub.1 is a straight or branched chain (C.sub.3 to C.sub.8) alkyl group substituted by one or two phosphate ester groups (e.g., a phosphate ester convertible in vivo into a hydroxy group) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.
REFERENCES:
patent: 4791111 (1988-12-01), Heeres et al.
patent: 5039676 (1991-08-01), Saksena et al.
Sinkula in Annual Reports Medicinal Chemistry, vol. 10, Chapter 31, pp. 306-315 (1975).
Bennett Frank
Ganguly Ashit K.
Girijavallabhan Viyyoor M.
Liu Yi-Tsung
Lovey Raymond G.
Bernhardt Emily
Hoffman Thomas D.
Schering Corporation
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