Tetrahydrofuran antifungals

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514 85, 5142278, 5142362, 544 60, 544121, 544337, 544357, 544364, 544366, 548112, 5482686, 5482688, 549559, 500254, 562840, A61K 31495, C07D40514, C07D41314, C07F 96518

Patent

active

057101540

ABSTRACT:
A compound represented by the formula I ##STR1## wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R.sub.1 is a straight or branched chain (C.sub.3 to C.sub.8) alkyl group substituted by one or two groups convertible in vivo into hydroxy moieties, (e.g., a polyether ester, amino acid ester or phosphate ester) thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.

REFERENCES:
patent: 4791111 (1988-12-01), Heeres et al.
patent: 5039676 (1991-08-01), Saksena et al.

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