Tetrahydrocarbazole esters, pharmaceutical compositions and use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

514411, 548253, 548439, A61K 31395, A61K 3141, C07D20982, C07D40302

Patent

active

049407198

ABSTRACT:
Tetrahydrocarbazole esters are disclosed. The compounds act as prostaglandin and thromboxane antagonists and are useful in treating asthma, diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion and dysmenorrhea and nephrotoxicity caused by cyclosporin A and as cytoprotective agents.

REFERENCES:
patent: 3896145 (1975-07-01), Berger et al.
patent: 4009181 (1977-02-01), Berger et al.
patent: 4057559 (1977-11-01), Asselin et al.
patent: 4808608 (1989-02-01), Guindon et al.
Shen et al, The Development of Antiasthmatic Drugs III, Butterworth Publisher, Kent, Engl 1981 pp. 315-317 and 331-335.

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