Tetrahydrocannabinol derivatives and protein and polypeptide tet

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

549 60, 549390, 536115, C07H 1302, C07D40906

Patent

active

052370577

ABSTRACT:
The present invention is directed to novel THC derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or receptors to the THC metabolites. The resulting novel antigens may be used for the production of antibodies or receptors using standard methods. Once generated, the antibodies or receptors and the novel derivatives which are covalently attached to proteins, polypeptides or labels may be used in the immunoassay process.

REFERENCES:
patent: 4690944 (1982-09-01), Chiesi et al.
patent: 4833073 (1989-05-01), McNally et al.
patent: 5144030 (1992-09-01), Wang et al.
Law, B., et al., Forensic Aspects of the Metabolism and Excretion of Cannabinol Following Oral Ingestion of Cannabis Resin, J. Pharm. Pharmacol. 36:289-294 (1984).
Schwartz, Alan and Madan, Pradeep, A Convenient Synthesis of 11-Nor-.DELTA.8-tetrahydrocannabinol-9-carboxylic Acid, J. Org. Chem. 51:5463-5465 (1986).
Wall, Monroe E. and Perez-Reyes, Mario, The Metabolism of .DELTA..sup.9 -tetrahydrocannabinol and Related Cannabinoids in Man, J. Clin. Pharmacol., 21:1785-1895 (1981).
Williams, P. L. and Moffat, A. C., Identification in Human Urine of .DELTA..sup.9 -tetrahydrocannabinol-11-OIC Acid Glucuronide: A Tetrahydrocannabinol Metabolite, J. Pharm. Pharmacol. 32:445-448 (1980).
Fahrenholtz, K. E., et al., The Total Synthesis of dl-.DELTA..sup.9 -Tetrahydrocannabinol and Four of its Isomers, J. Am. Chem. Socy. 89:5934-5941 (1967).
Nordqvist, M., et al., Identification of a Major Metabolite of Tetrahydrocannabinol in Plasma and Urine from Cannabis Smokers, in Mass Spectrometry on Drug Metabolism (E. Ghisalberai, ed.) Plenum Press, N.Y. (1977).
Pitt, Colin G., et al., The Preparation of 5'-Iodo-.sup.125 I-.DELTA..sup.8 -THC; A Radioligand for the Radioimmunoassay of Cannabinoids, J. Labelled Comp. and Radiopharmaceuticals, 17:681-689 (1978).
Pitt, C. G., et al., The Synthesis of Deuterium, Carbon-14, and Cancer Free Tritium Labeled Cannabinoids, J. Labelled Comp. 11:551-575 (1978).
Rodgers, Richard et al., Homogeneous Enzyme Immunoassay for Cannabinoids in Urine, Clin. Chem. 24:95-100 (1978).
Mago, E., et al., An Alternative Route for the Synthesis of Unlabelled and Labelled Delta-1-tetrahydrocannabinol-7-OIC acid, reprinted in Marihuana '84 Proceedings of the Oxford Symposium on Cannabis (D. J. Harvey, ed.) IRL Press, Ltd., Oxford, England (1984).
Seltzmann, H. H., et al., Syntheses of Cannabinoid Radioligands and Haptens for Use in Radioimmunoassay and Receptor Site Studies, Reprinted in Marihuana '84 Proceedings of the Oxford Symposium on Cannabis (D. J. Harvey, ed.) IRL Press, Ltd., Oxford, England (1984).
Al-Hakawati, M. I. and Paris, M., Advanced High Pressure Liquid Chromatography (HPLC) Method for the Analysis of Cannabinoids in Cannabis sativa L., reprinted in Marihuana '84 Proceedings of the Oxford Symposium on Cannabis (D. J. Harvey, ed.) IRL Press, Ltd., Oxford England (1984).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Tetrahydrocannabinol derivatives and protein and polypeptide tet does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tetrahydrocannabinol derivatives and protein and polypeptide tet, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tetrahydrocannabinol derivatives and protein and polypeptide tet will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2245140

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.