Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-03-24
1999-03-23
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514285, 514292, 546 70, 546 85, 546 86, 5462767, A61K 3144, C07D47104, C07D48704
Patent
active
058860045
ABSTRACT:
The present invention provides novel tetrahydro-beta-carboline compounds having useful central nervous system activity. The invention provides formulations and methods for using the novel tetrahydro-beta-carboline and related compounds. Such compounds are particularly useful for the modulation of a 5-HT.sub.2B receptor.
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Wainscott, David B., et al., "Pharmacologic Characterization of the Human 5-Hydroxytryptamine.sub.2B Receptor: Evidence for Species Differences", JPET, 276:720-727, (1996).
Kametani, et al., "Studies on the syntheses of heterocyclic compounds DCXLI. A convenient synthesis of hexadehydroyohimbine and a total synthesis of yohimbine.", Chem. Pharm. Bull. 23:11, pp. 2634-2642, (1975).
Audia James E.
Nelson David L. G.
Eli Lilly and Company
Palmberg Arleen
Shah Mukund J.
Sripada Pavanaram K
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