Tetrahydrobenzo[d]azepin-2-one derivatives and the use...

Details Tetrahydrobenzo[d]azepin-2-one derivatives and the use... Tetrahydrobenzo[d]azepin-2-one derivatives and the use...

2005-02-01

2010-02-16

Landau, Sharmila Gollamudi (Department: 1611)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C514S212070, C514S212080

Reexamination Certificate

active

07662956

ABSTRACT:
The present application relates to novel tetrahydrobenzo[d]azepin-2-one derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders, especially of dyslipidaemias, arteriosclerosis, restenosis and ischaemias.

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Vippagunta, Sudha R. “Crystalline Solids.” Advanced Drug Delivery Reviews 48(2001): 3-26.
Pandit et al. Journal of Biological Chemistry, “Crystal Structure of Human Squalene Synthase” vol. 275(39) 2000, 30610-30617.
G. Assmann et al.: “The Münster Heart Study (PROCAM),” European Heart Journal, vol. 19, Supp. A., 1998, pp. A2-A11.
N. S. Watson et al.: “7 Squalene Synthase Inhibitors: Their Potential as Hypocholesterolaemic Agents,” Progress in Medicinal Chemistry, vol. 33, 1996, pp. 331-378.
H. Hiyoshi et al.: “Squalene Synthase Inhibitors Reduce Plasma Triglyceride Through a Low-Density Lipoprotein Receptor-Independent Mechanism,” European Journal of Pharmacology, vol. 431, 2001, pp. 345-352.

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