Tetrahydrobenzimidazole derivatives and pharmaceutical compositi

Details Tetrahydrobenzimidazole derivatives and pharmaceutical compositi Tetrahydrobenzimidazole derivatives and pharmaceutical compositi

1993-03-30

1994-09-06

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544105, 544331, 546121, 546159, 546168, 548139, 548184, 548185, 5483047, 5483051, 5483054, 5483057, 5483061, A61K 31505, A61K 3147, C07D23504, C07D23942, C07D40100

Patent

active

053449274

ABSTRACT:
A tetrahydrobenzimidazole derivative represented by formula (I): ##STR1## wherein Het represents a heterocyclic group which may be substituted with 1 to 3 substituents selected from the group consisting of a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a cycloalkyl-lower alkyl group, an aralkyl group, a lower alkoxy group, a nitro group, a hydroxyl group, a lower alkoxycarbonyl group, and a halogen atom; and X represents a single bond or --NH-- which is bonded to the carbon atom or nitrogen atom of the heterocyclic ring, or a pharmaceutically acceptable salt thereof.
The compound of formula (I) and a salt thereof exhibits antagonism against 5-HT.sub.3 receptor.

REFERENCES:
patent: 3772315 (1973-11-01), Regel et al.
patent: 3873558 (1975-03-01), Grenda et al.
patent: 3907700 (1983-09-01), Grier
patent: 4414214 (1989-11-01), Habichi et al.
patent: 4820757 (1989-04-01), Spang et al.
patent: 5008397 (1991-04-01), Spang et al.
patent: 5149700 (1992-09-01), Ellingboe et al.

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