Tetrahydrobenzfluorene derivatives

Details Tetrahydrobenzfluorene derivatives Tetrahydrobenzfluorene derivatives

2007-10-25

2010-02-02

Shameem, Golam M (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S106000, C544S154000, C544S358000, C546S184000, C546S248000, C548S528000, C514S231200, C514S252120, C514S315000

Reexamination Certificate

active

07655653

ABSTRACT:
A compound having the formula Iwhereinthe O—(CH2)n—N(R1,R2) substituent on the phenyl ring can be in meta or para position;n is 2-4Reand ′Reare OH, optionally independently etherified or esterified;R1and R2are independently (1C-4C)alkyl, (2C-4C)alkenyl, hydroxy(2C-4C)alkyl, (1C-3C)alkoxy(2C-4C)alkyl, aryl or aryl(1C-2C)alkyl; or R1and R2together with the nitrogen form an aromatic or non-aromatic heterocyclic ring structure, optionally mono- or poly-substituted with (1C-4C)alkyl, (2C-4C)alkenyl, hydroxy(1C-2C)alkyl, (1C-2C)alkoxy(1C-3C)alkyl or aryl. These compounds can be used for estrogen receptor β selective medical treatments.

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Tedesco, R. et al. “Synthesis and Evaluation of hexahydrochrysene and tetrahydrobenzofluorence Ligands for the Estrogen Receptor,”Bioorg Med Chem Lett11 (2001) 1281-1284, XP001503388 cited in the application p. 1282.
Tedesco, R. et al, “Snythesis and Evaluation of hexahydrochrysene and Tetrahydrobenzofluorence Ligands for the Estrogen Receptor” Bioorganic & Medicinal Chemistry Letters (2001), 11(10), 1281-1284, May 21, 2001 XP001053388 cited in the application p. 1282.

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