Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2001-11-12
2008-09-30
Coleman, Brenda L (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S594000
Reexamination Certificate
active
07429579
ABSTRACT:
The invention provides compounds of formula (I): wherein: R2and R3independently represent various substituents; R1and R4independently represent H, F, Cl, Br, C1-2alkyl, C1alkoxy, OH, CN, or NO2; B represents a sulfur atom or a —CH2-group; t represents 3 or 4; and A represents an optionally substituted 5- or 6-membered aromatic heterocyclic ring, or an optionally substituted bicyclic heterocyclic ring system in which at least the ring bound to the group B in Formula (I) is aromatic; or a salt thereof. Preferably, A is selected from one of the groups (i), (ii) or (iii): wherein X1and X2are independently N or CR8, and X3is NR8, O or S; Y1and Y3are independently N or CR9, and Y2is NR9, O or S; Z1is NR10, O or S, and Z2and Z3are independently N or CR10; R8, R9, and R10are as herein defined, and R7is H, a halogen atom, OH, cyano, nitro, C1-4alkyl, C1-4alkoxy, C1-4alkylenedioxy, C1-4alkanoyl, or C1-4alkylsulfonyl, an optionally substituted 3-, 4-, 5- or 6-membered cycloalkyl ring, or a group of the formula (a), (b), (c) or (d) as defined by the formulas (a), (b), (c) or (d). The compounds are modulators of dopamine D3receptors and have potential in the treatment of psychotic conditions (e.g. schizophrenia) or substance abuse.
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Austin, N. E. et al., “Novel 2,3,4,5-tetrahydro-1H-3-benzazepines with high affinity and selectivity for the dopamine D3 receptor”., Bioorganic & Medicinal Chemistry Letters, Oxford, GB, Vo. 10., No. 22, Nov. 20, 2000 (pp. 2553-2555, XP004224262.
Hadley Michael Stewart
Lightfoot Andrew
MacDonald Gregor James
Stemp Geoffrey
Coleman Brenda L
Kanagy James M.
Kinzig Charles M.
SmithKline Beecham PLC
Venetianer Stephen
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