Tetrahydro isoquinoline derivatives, preparation methods and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C546S146000

Reexamination Certificate

active

07820692

ABSTRACT:
A kind of tetrahydro isoquinoline derivatives (I), their preparation methods, medicine compositions and medicinal uses thereof, especially their uses as κ-opioid receptor excitant in pain relieving, which belongs to the medicine chemistry. The substituents R1, R2, R3, R4of general formula (I) are defined as the description.

REFERENCES:
patent: 2006/0104907 (2006-05-01), Lazarus et al.
patent: 1887872 (2007-01-01), None
patent: WO 97/31940 (1997-09-01), None
Joel R. Huff, HIV Protease: A Novel Chemotherapeutic Target for AIDS, 1991, Journal of Medicinal Chemistry, vol. 34, No. 8, 2305-2314.
International Search Report, dated Sep. 6, 2007, correspodning to PCT/CN2007/002115.

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