Tetrahydro-beta-carbolines

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514292, 546 70, 546 86, 546 87, A61K 3144, C07D47104, C07D48704

Patent

active

058614109

ABSTRACT:
The present invention provides novel tetrahydro-beta-carboline compounds having useful central nervous system activity. Further, there is provided tetrahydro-beta-carboline related compounds which are useful intermediates and have beneficial central nervous system activity. The invention provides formulations and methods for using the novel tetrahydro-beta-carboline and related compounds. Such compounds are particularly useful for the modulation of a 5-HT.sub.2B receptor.

REFERENCES:
Derwent Abstract 03884Y/03 Jun. 25, 1975 BE-843-215.
Derwent Abstract 68225 c/39 Feb. 5,1979 EP--15-786.
Derwent Abstract 84-115276/19 Oct. 29, 1982 DE-3240-514-A.
Derwent Abstract 40991 Apr. 14, 1967 US/3,840,637.
Dubois, et al., J. Org. Chem., 59, 434-441 (1994).
Legters, et al., Rccl. Trav. Chim. Pays-Bas, 111, 16-21 (1992).
Sato, K. And Kozikowski, A. P., Tetrahedron Letters, 30:31., 4073-4076, (1989).
Shima, et al., Chem. Pharm. Bull., 38:2, 564-566 (1990).

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