Tetrahydro-Beta-Carbolines

Details Tetrahydro-Beta-Carbolines Tetrahydro-Beta-Carbolines

1997-04-08

1999-01-19

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 49, 546 70, A61K 3144, C07D47104, C07D47110

Patent

active

058614087

ABSTRACT:
The present invention provides novel tetrahydro-beta-carboline compounds having useful central nervous system activity. Further, there is provided tetrahydro-beta-carboline related compounds which are useful intermediates and have beneficial central nervous system activity. The invention provides formulations and methods for using the novel tetrahydro-beta-carboline and related compounds. Such compounds are particularly useful for the modulation of a 5-HT.sub.2B receptor.

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Sato, K. And Kozikowski, A. P., Tetrahedron Letters, 30:31., 4073-4076, (1989).
Shima, et al., Chem. Pharm. Bull., 38:2, 564-566 (1990).

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