Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1984-05-18
1986-09-16
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 85, 546 87, A61K 31435, C07D47104
Patent
active
046123172
ABSTRACT:
Tetrahydro-.beta.-carboline derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen atom, a lower alkyl group, a cycloalkyl group, phenyl group or a hydroxy-substituted lower alkyl group, R.sup.2 is hydrogen atom, an alkyl group, or a group of the formula: --(CH.sub.2).sub.m Y, Y is thienyl or a substituted or unsubstituted phenyl group, and m and n are an integer of 1 or 2, which have excellent alleviating, curing and preventing hepatic damages and are useful as a therapeutic or prophylactic agent for hepatic diseases, and a process for the preparation of said compounds.
REFERENCES:
patent: 2187719 (1940-01-01), Williams
Zimmerman, H. J., "Hepatotoxicity-The Adverse Effects of Drugs and Other Chemicals on the Liver", Appleton-Century-Crofts, New York (1978).
Iijima Ikuo
Matsumoto Mamoru
Matsuoka Yuzo
Miyagishima Toshikazu
Saiga Yutaka
Bjorkman Dale A.
Jiles Henry R.
Tanabe Seiyaku Co. Ltd.
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