Tetrahydro-2H-thiopyran-4-carboxamide derivative

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S359000, C548S131000, C548S100000

Reexamination Certificate

active

06903125

ABSTRACT:
A pharmaceutical drug, particularly a novel compound useful for the prophylaxis or therapeutic treatment of various diseases involving infections with viruses of the Herpesviridae family, specifically various herpesvirus infections such as varicella (chicken pox) via varicella zoster virus, varicella zoster via recurrent infection with latent varicella zoster virus, herpes labialis and herpes encephalitis via HSV-1 and genital herpes via HSV-2 infection. N-{2-[(4-Substituted phenyl)amino]-2-oxoethyl}tetrahydro-2H-thiopyran-4-carboxamide derivative where the phenyl group is substituted at position 4 with a specific five-membered or 6-membered heteroaryl group, has such great anti-virus activity that the oral dosing thereof at a low dose enabled the therapeutic treatment of the diseases.

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patent: 6288091 (2001-09-01), Crute et al.
patent: 6458959 (2002-10-01), Crute et al.
patent: 6500817 (2002-12-01), Fisher et al.
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patent: 6638980 (2003-10-01), Su et al.
patent: 2004/0034232 (2004-02-01), Kontani et al.
patent: WO 00/29399 (2000-05-01), None
patent: WO 03/013531 (2003-02-01), None
patent: WO 03/095435 (2003-11-01), None

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