Tetrahydro-1,3,thiazine-2,4 diones, use thereof and skin treatin

Details Tetrahydro-1,3,thiazine-2,4 diones, use thereof and skin treatin Tetrahydro-1,3,thiazine-2,4 diones, use thereof and skin treatin

1988-03-02

1989-11-28

Ore, Dale R.

Drug, bio-affecting and body treating compositions

Topical sun or radiation screening, or tanning preparations

424 47, 424 63, 424 64, 514844, 514846, 514847, 514873, 514938, 514939, A61K 740, A61K 742, A61K 748

Patent

active

048836524

ABSTRACT:
Skin treating composition on the basis of compatible carrier and additional compositions with a content of a defined tetrahydro-1,3-thiazine-2,4-dion derivatives as active ingredients for thickening the epidermis. The skin treating compositions are applied 1-2 times daily onto the skin for about 3 to 4 weeks. Due to the thickening of the epidermis they cause a reinforcement of the skin, in particular against sun rays, cold and the contact with noxious environmental substances of all kinds. Moreover, the skin treating compositions are suitable for a prophylactic fighting of the so-called old age skin. An object of the invention are novel tetrahydro-1,3-thiazine-2,4-dion derivative which are active in the aforementioned manner having the formula ##STR1## wherein R denotes H, alkyl, aryl, arylalkyl has substituted arylalkyl or substituted aryl in the aryl portion, R.sup.2 =H is aryl or substituted aryl, R.sup.b =H, denotes aryl or substituted aryl and R.sup.3 =H, represents alkyl or aryl, provided that R.sup.a, R.sup.b and R.sup.c only simultaneously denote H when R denotes a substituted arylalkyl in the aryl portion and R denotes H, but only if R.sup.a =HR.sup.b =aryl and R.sup.c constitute=H.

REFERENCES:
patent: 2948657 (1960-08-01), Siccama
patent: 3781418 (1973-12-01), Poniot

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