Tetrahydro-1,3-thiazin-2,4-dione derivatives

Details Tetrahydro-1,3-thiazin-2,4-dione derivatives Tetrahydro-1,3-thiazin-2,4-dione derivatives

1987-03-24

1988-05-24

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 55, A61K 3138, C07D27906, C07D27904

Patent

active

047467380

ABSTRACT:
Skin treating composition on the basis of compatible carrier and additional compositions with a content of a defined tetrahydro-1,3-thiazine-2,4-dion derivatives as active ingredients for thickening the epidermis. The skin treating compositions are applied 1-2 times daily onto the skin for about 3 to 4 weeks. Due to the thickening of the epidermis they cause a reinforcmenet of the skin, in particular against sun rays, cold and the contact with noxious environmental substances of all kinds. Moreover, the skin treating compositions are suitable for a proplylactic fighting of the so-called old age skin. An object of the invention are novel tetrahydro-1,3-thiazine-2,4-dion derivative which are active in the aforementioned manner having the formula ##STR1## wherein R denotes H, alkyl, aryl, arylalkyl has substituted arylalkyl or substituted aryl in the aryl portion, R.sup.a =H is aryl or substituted aryl, R.sup.b =H, denotes aryl or substituted aryl and R.sup.c -H, represents alkyl or aryl, provided that R.sup.a, R.sup.b and R.sup.c only simultaneously denote H when R denotes a substituted arylalkyl in the aryl portion and R denotes H, but only if R.sup.a =HR.sup.b =aryl and R.sup.c constitute=H.

REFERENCES:
patent: 2585064 (1950-02-01), Wheeler et al.
patent: 4352929 (1982-10-01), Anderson et al.
patent: 4421749 (1983-12-01), Pauling
N. A. Langlet, Ofversigt af kongl. (Svenska) Vetenskaps-Akademiens Forhandlinger 1892, p. 166.
E. V. Vladzimirskaya, Zh. Obshch. Khim. 31, p. 1921 (1961); C A. 55, 27328 (1961).
W. Hanefeld, Justus Liebigs Ann. Che., 1974, p. 2015-2018.
K. Takemoto, H. Tahara, Y. Inaki, N. Ueda, Chem. Lett. 1972, p. 767.
E. Campaigne, P. K. Nargrund, J. Med. Chem. 7, (1964), p. 132.
W. Hanefeld, Arch. Pharm. (Weinheim) 314, (1981), pp. 315-328.
W. Hanefeld, Justus Liebigs, Ann. Chem. 1974, pp. 1789-1792.
Rothlisberger et al, Abstract of D.E. 2938418, published 4/9/81.

Affiliated with

Also associated with

Rating

Tetrahydro-1,3-thiazin-2,4-dione derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tetrahydro-1,3-thiazin-2,4-dione derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tetrahydro-1,3-thiazin-2,4-dione derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1059331