Tetraenyl prostaglandins

Details Tetraenyl prostaglandins Tetraenyl prostaglandins

1987-06-30

1989-04-11

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514573, 560118, 562500, C07C17700, A01K 31557

Patent

active

048207284

ABSTRACT:
This invention encompasses prostaglandins of the formula ##STR1## wherein R represents hydrogen or lower alkyl having 1 to 6 carbon atoms; R.sub.1 represents hydrogen, vinyl, or lower alkyl having 1 to 4 carbon atoms and the wavy line represents R or S stereochemistry; R.sub.2, R.sub.3, and R.sub.4 are hydrogen or lower alkyl having 1 to 4 carbom atoms or R.sub.2 and R.sub.3 together with carbon Y form a cycloalkenyl having 4 to 6 carbon atoms or R.sub.3 and R.sub.4 together with carbons X and Y form a cycloalkenyl having 4 to 6 carbons. Compounds of this invention have potent gastric antisecretory and cytoprotective properties with unexpectedly low diarrheogenic side effects.

REFERENCES:
patent: 3965143 (1976-06-01), Collins
patent: 4499296 (1985-02-01), Collins
patent: 4536592 (1985-08-01), Collins
patent: 4683328 (1987-07-01), Collins

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