Tetradecadienoic acid, a glycosyl phosphatidylinositol (GPI) ana

Details Tetradecadienoic acid, a glycosyl phosphatidylinositol (GPI) ana Tetradecadienoic acid, a glycosyl phosphatidylinositol (GPI) ana

1996-03-18

1998-06-02

Walsh, Stephen

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

514557, 514558, 514560, C07K 5703, A61K 3120

Patent

active

057602590

ABSTRACT:
A method of inhibiting parasitic activity is disclosed in which the biosynthesis, structure and/or function of the glycotyl phosphatidylinositol (GPI) anchor of said parasite may be affected by incorporating into said GPI anchor selected analogs of myristic acid containing various heteroatoms, substituents and unsaturated bonds, including ester-containing analogs, ketocarbonyl-containing analogs, sulfur-containing analogs, double bond- and triple bond-containing analogs, aromatic moiety-containing analogs, nitrated analogs and halogenated analogs.

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