Tetracycline inducible/repressible systems

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

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4353201, 536 241, C12N 500, C12N 1500, C07H 2104

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active

058917187

ABSTRACT:
This application relates to effector controlled eukaryotic expression vectors adapted for use in gene therapy or gene immunization having positive feedback regulation.

REFERENCES:
patent: 5464758 (1995-11-01), Gossen et al.
Kim. H-J.. et al. (1995) Tetracycline Repressor-Regulated Gene Repression in Recombinant Human Cytomegalovirus. Journal of Virology 69(4):2565-2573.
Shockett, P.. et al. (1995) A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice. Proc. Natl. Acad. Sci. 92:6522-6526.
Acsadi, G., et al. (1991) Human dystrophin expression in mdx mice after intramuscular injection of DNA constructs. Nature 352:815-818.
Chapman B., et al. (1991) Effect of intron A from human cytomegalovirus (Towne) immediate-early gene on heterologous expression in mammalian cells. Nucleic Acids Research 19(14):3979-3986.
Choi, T., et al. (1991) A generic intron increases gene expression in transgenic mice. Molecular and Cellular Biology 11(6):3070-3074.
Conry, R., et al. (1995) A carcinoembryonic antigen polynucleotide vaccine has in vivo antitumor activity. Gene Therapy 2:59-65.
Davis, H., et al. (1993) DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody. Human Molecular Genetice 2(11):1847-1851.
Deuschle, U., et al. (1995) Tetracycline-reversible silencing of eukaryotic promoters. Molecular and Cellular Biology 15(4):1907-1914.
Elory-Stein, O., et al. (1989) Cap-independent translation of mRNA conferred by encephalomyocarditis virus 5' sequence improves the performance of the vaccinia virus/bacteriophage T7 hybrid expression system. Proc. Natl Acad. Sci. 86:6126-6130.
Felgner, P., et al. (1991) The direct delivery of purified genes in vivo and their application as drugs, without the use of retroviruses, is discussed. Gene therapeutics 349:351-352.
Felgner, J., et al. (1994) Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations. The Journal of Biological Chemistry 269:2550-2561.
Fishman, G., et al. (1994) Tetracycline-regulated cardiac gene expression in vivo. J. Clin. Invest. 93:1864-1868.
Furth, P., et al. (1994) Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter. Proc. Natl. Acad. Sci. 91:9302-9306.
Gatz, C., et al. (1992) Stringent repression and homogeneous de-repression by tetracycline of a modified CaMV 35S promoter in intact transgenic tobacco plants. The Plant Journal 2(3);397-404.
Gossen, M., et al. (1993) Control of gene activity in higher eukaryotic cells by prokaryotic regulatory elements. TIBS 471-475.
Gossen, M., et al. (1995) Transcriptional activation by tetracyclines in mammalian cells. Science 268:1766-1769.
Gossen, M., et al. (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. 89:5547-5551.
Hawkins, R., et al. (1993) A genetic approach to idiotypic vaccination. Journal of Immunotherapy 14:273-278.
Hinrichs, W., et al. (1994) Structure of the tet repressor-tetracycline complex and regulation of antibiotic resistance. Science 264:418-420.
Horn N., et al. (1995) Cancer gene therapy using plasmid DNA: purification of DNA for human clinical trials. Human Gene Therapy 6:565-573.
Jans, D., et al. (1994) Negative charge at the casein kinase II site flanking the nuclear localization signal of the SV40 large T-antigen is mechanistically important for enhanced nuclear import. Oncogene 9:2961-2968.
Kalderon, D., et al. (1984) A short amino acid sequence able to specify nuclear location. Cell 39:499-509.
Lew, D., et al. (1995) Cancer gene therapy using plasmid DNA: pharmacokinetic study of DNA following injection in mice. Human Gene Therapy 6:553-564.
Manthorpe, M., et al. (1993) Gene therapy by intramuscular injection of plasmid DNA: studies on firefly luciferase gene expression in mice. Human Gene Therapy 4:419-431.
Morgan, R., et al. (1992) Retroviral vectors containing putative internal ribosome entry sites: development of a polycistronic gene transfer system and applications to human gene therapy. Nucleic Acids Research 20(6):1293-1299.
Nabel, G., et al. (1993) Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans. Proc. Natl. Acad. Sci. 90:11307-11311.
Parker, S., et al. (1995) Cancer gene therapy using plasmid DNA: safety evaluation in rodents and non-human primates. Human Gene Terapy 6:575-590.
Perales, J., et al. (1994) Gene transfer in vivo: sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake. Proc. Natl. Acad. Sci. 91:4086-4090.
Pescini, R., et al. Regulatable gene activation/inhibition using a powerful genetic switch. Technology Advances for Gene Therapy.
Sankaran, L., et al. (1992) A simple quantitative assay for chloramphenicol acetyltransferase by direct extraction of the labeled product into scintillation cocktail. Analytical Biochemistry 200:180-186.
Sedegah, M., et al. (1994) Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein. Proc. Natl. Acad. Sci. 91:9866-9870.
Ulmer, J., et al. (1993) Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259:1745-1749.
Wolff, J., et al. (1990) Direct gene transfer into mouse muscle in vivo. Science 247:1465-1468.
Yoshimura., K., et al. (1992) Expression of the human cystic fibrosis transmembrane conductance regulator gene in the mouse lung after in vivo intratracheal plasmid-mediated gene transfer. Nucleic Acids Research 20(12):3233-3240.
Chen, X., et al. (1994) A self-initiating eukaryotic transient gene expression system based on cotransfection of bacteriophage T7 RNA polymerase and DNA vectors containing a T7 autogene. Nucleic Acids Research 22(11):2114-2120.
E. Marshall (1995) Science 269:1050-1055.
N. Miller et al (1995) Targeted Gene Therapy 9:190-199.

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