Tetracycline dosage form

Details Tetracycline dosage form Tetracycline dosage form

1990-05-14

1994-01-11

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424468, 424470, 424474, 424479, 424480, 424482, 424490, 424493, 424497, A61K 928, A61K 932

Patent

active

052779165

ABSTRACT:
A tetracycline pharmaceutical composition having a core element containing a tetracycline antibiotic and a core coating which dissolves more slowly in the stomach than in the intestine. Administration of the composition to a human results in drug concentrations in the blood which are bioequivalent to those achieved with immediate release formulations.

REFERENCES:
patent: 3499959 (1970-03-01), Corn
patent: 3538214 (1970-11-01), Polli
patent: 4606909 (1986-08-01), Bechgaard et al.
patent: 4837030 (1989-06-01), Valorose, Jr. et al.
A. A. El-Sayed, et al. (Aug. 1978) Manu. Chem. Aero. News, pp. 52-54, 1978.
Saurabh J. Desal, et al. (1966) J. Pharm. Sciences, vol. 55, No. 11, pp. 1224-1229.
Saurabh J. Desal, et al. J. Pharm. Sciences, vol. 55, No. 11, pp. 1230-1234.
T. Higuchi (1963) J. Pharm. Sciences, vol. 55, No. 11, pp. 1245-1249.
E. Nelson (1959) J. Am. Pharma. Assoc., vol. XLVIII(2), pp. 96-103.

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