Tetracycline activity enhancement using doxycycline or sancyclin

Details Tetracycline activity enhancement using doxycycline or sancyclin Tetracycline activity enhancement using doxycycline or sancyclin

1991-03-20

1993-11-02

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

3,10-dihydroxy-2-naphthacene carboxamide or derivative doai

514152, A61K 3165

Patent

active

052583724

ABSTRACT:
Methods and products for overcoming bacterial resistance to tetracycline-type antibiotics by inhibiting the plasmid-mediated active efflux system for tetracycline in the resistant bacterial cell by administering with tetracycline efflux system blocking agents of doxycycline or sancycline, thereby increasing the sensitivity of the resistant cell to tetracycline type antibiotics.

REFERENCES:
patent: 3454697 (1969-07-01), Joyner et al.
patent: 4024272 (1977-05-01), Rogalaski et al.
patent: 4126680 (1978-11-01), Armstrong
patent: 4806529 (1989-02-01), Levy
Grassi et al., New Trends in Antibodies: Research and Therapy, pp. 3-54 (1981).
CA: 89: 71494n (Connamacher et al.) (1978).
CA: 90: 198211u (Samra et al.) (1979).
CA: 83: 1393f (Candanoza et al.) (1975).
CA: 81: 115200e (Leigh et al.) (1974).
CA: 82: 26560a (Lebek et al.) (1975).
CA: 74: 74941g (Kuck et al.) (1971).

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