Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 3,10-dihydroxy-2-naphthacene carboxamide or derivative doai
Patent
1982-11-18
1989-02-21
Meyers, Albert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
3,10-dihydroxy-2-naphthacene carboxamide or derivative doai
424116, 424117, A61K 3165, A61K 3500
Patent
active
048065293
ABSTRACT:
Methods and products for overcoming bacterial resistance to tetracycline-type antibiotics by inhibiting the plasmid-mediated active efflux system for tetracycline in the resistant bacterial cell by administering with tetracycline efflux system blocking agents, thereby increasing the sensitivity of the resistant cell to tetracycline type antibiotics.
REFERENCES:
patent: 3454697 (1969-07-01), Joyner et al.
patent: 4024272 (1977-05-01), Rogalski et al.
patent: 4126680 (1978-11-01), Armstrong
Grassi et al, New Trends in Antibiotics: Research and Therapy, pp. 3-54 (1981).
Chem. Abst. 89:71494n (Connamacher) et al.).
Chem. Abst. 90:198211u (Sanura et al.).
Chem. Abst 83:1393f (Candanoza et al.).
Chem. Abst. 81:115200e (Leigh et al.). Chem. Abst. 82:26560a (Lebek et al.).
Chem. Abst. 74:74941g (Kuck et al.).
Chem. Abst. 79:741781n (Kuck et al. I).
Chem. Abst. 86:150977p (Williams et al.).
Chem. Abst. 79:143198n (Sompolinsky et al.).
Levy, S. B. "The Tetracyclines: Microbial Sensitivity and Resistance," New Trends in Antibiotics: Research and Therapy, Elsevier/North-Holland Biomedical press, 1981, pp. 27-44.
Chapra, et al. "The Tetracyclines: Prospects at the Beginning of the 1980's," Journal of Microbial Chemotherapy, 8:5-21(1981).
Lehninger, Biochemistry--The Molecular Basis of Cell Structure and Function (2 ed., Worth Publishers, 1975) p. 941.
Mendez, B., et al, "Heterogeneith of Tetracyclines: Resistance, Determinants," Plasmid, 3:99-108 (1980).
Levy and McCurry, "Detection of an Inducible Membrane Protein Associated with R-Factor Mediated Tetracycline Resistance," Biochemical and Biophysical Research Commun. 56(4):1060-1068 (1974).
Levy and McCurry, "Plasmid-Determined Tetracycline Resistance Involves New Transport Systems for Tetracycline," Nature; 275 (5683); 90-92 (1978).
McCurry and Levy, "Two Transport Systems for Tetracycline in Sensitive Escherichia Coli: Critical Role for an Initial Rapid Uptake System Insensitive to Energy Inhibitors" Antimicrobial Agents and Chemotherapy 14(2):201-209 (1978).
McCurry, et al, "Active Efflux of Tetracycline Encoded by Four Genetically Different Tetracycline Resistance Determinants in Escherichia Coli," Proc. Nat. Acad. of Sci., U.S.A. 77(7):3975-3977 (1980).
Curiale and Levy., "Two Complementation Groups Mediate Tetracycline Resistance Determined by Tn10", Journal of Bacteriology, 151(1); 209-215 (1982).
Korolkovas, A., et al. Essentials of Medicinal Chemistry (John Wiley & Sons, Inc., 1976) at 512-517.
"Active Uptake of Tetracycline by Membrane Vesicles from Susceptible Escherichia Coli," Antimicrobial Agents and Chemotherapy 20(3): 307-313 (1981).
Brock, et al, "Comparison of the In Vitro Serum Microbiological Activity of a Triple Tetracycline Tablet, 300 mg B.I.D. with Oxytetracycline, 250 mg Q.I.D.," J. Int. Med. Res. (1981) 9,360.
Conlin David G.
Krosnick Freda L.
Meyers Albert T.
Trustees of Tufts College, Tufts University
Williams Gregory D.
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