Tetracyclic condensed heterocyclic compounds and their use

Details Tetracyclic condensed heterocyclic compounds and their use Tetracyclic condensed heterocyclic compounds and their use

1994-10-25

1997-04-15

Datlow, Philip I.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540576, 544372, 546 71, 546 72, 546200, C07D48704, A61K 3155

Patent

active

056209738

ABSTRACT:
A novel compound of the formula ##STR1## wherein Ar represents a tetracyclic fused heterocyclic group which may be substituted; R.sup.1 represents H or a hydrocarbon group which may be substituted; Y represents an amino or nitrogen-containing saturated heterocyclic group which may be substituted, its salt, inhibiting excellent cholinesterase inhibitory activity and monoamine uptake inhibitory activity, thus being useful as therapeutic and/or prophylactic medicaments of senile dementia.

REFERENCES:
patent: 3403156 (1968-09-01), Humber et al.
patent: 4192874 (1980-03-01), Glamkowski et al.
patent: 5273974 (1993-12-01), Goto et al.
Kumar et al., Treatment of Alzheimer's disease with cholinergic drugs, International Journal of Clinical Pharmacology, Therapy and Toxicology, vol. 29, No. 1,1991, pp. 23-37.
Ogino et al., Photocycloadditions of p-Quinones to Ketenimines, J. C. S. Perkin I, 1979, pp. 1552-1559.
Ishihara et al., Synthesis of Isoindolo[2,1-a]-quinoline Derivatives . . . , Chem Pharm Bull., vol. 38, No. 11, 1990, pp. 3024-3030.
Rehacek et al., Ergot Alkaloids, Bioactive Molecules, vol. 12, 1990, pp. 68-76.
Walker et al., Novel Syntheses of 1,4-Benzodiazepines, Isoindolo[2,1-d][1,4]benzodiazepines, . . . , Journal of Organic Chemistry, vol. 37, No. 24, 1972, pp. 3755-3770.
Pecca et al., Synthetic Trypanocides., Journal of Medicinal Chemistry, vol. 14, No. 5, 1971 pp. 448-449.
Itoh et al., Synthesis and Angiotensin Converting Enzyme-Inhibitory Activity . . . , Chem. Pharm. Bull., vol. 34, No. 9, 1986, pp. 3747-3761.
Blicke, The Mannich Reaction, Organic Reactions vol. 1, Chapter 10, pp. 303-341, (1942).
J.D. Sweatt et al., Archives Internationales de Phartmacodynamie et de Therapie, 1982, 257:188-199.
M. Leboeuf et al., Annales Pharmaceutiques Francaises, 1980, 38(6):537-544.
J.D. Sweatt et al., Archives Internationales de Pharmacodynamie et de Therapie, 1982, 257:188-199.
M. Hirobe et al., Chemical Abstracts, Abstract 181036j, 1980, 92(21):641.
G.N. Artemenko et al, Chemical Abstracts, Abstract 69985g, 1972, 77(11):11.
L.A. Aksanova et al., Chemical Abstracts, Abstract 34140e, 1972, 76(7):310.
N.J. Doorenbos et al., Journal of Pharmaceutical Sciences, 1971, 60(8):1236-1238.
N.M. Sharkova et al., Chemical Abstracts, Abstract 115036d, 1969, 70(25):335.

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