Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-04-29
1999-11-16
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549275, 549279, A61K 3135, A61K 31365, C07D31178
Patent
active
059859130
ABSTRACT:
The present invention provides a compound in substantially pure form having the structure: ##STR1## wherein each of R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, and R.sub.8 may independently be hydrogen, halogen, nitro, CF.sub.3, hydroxy, C.sub.1-5 alkyl, aryl or OR.sub.9, wherein R.sub.9 is C.sub.1-5 alkyl, wherein R.sub.10 is COC.sub.1-5 alkyl; or wherein any two consecutive R groups may be members of a C.sub.5 -C.sub.6 membered ring, and wherein the intracyclic-dashed line represents a covalent bond which may be present or absent, with the proviso that when R.sub.10 is present, the exocyclic-covalent bond is absent, and when R.sub.10 is absent, the exocyclic-covalent bond is present, and with the proviso that when R.sub.10 is absent, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, and R.sub.8 cannot all be hydrogen and when R.sub.10 is absent, R.sub.5, R.sub.6, R.sub.7, and R.sub.8 cannot all be hydrogen when either R.sub.1, R.sub.2, R.sub.3, or R.sub.4 is hydroxy, or R2 is carboethoxy. The present invention further provides a composition comprising the compound described above in an amount effective to modulate cellular expression of a mammalian gene encoding erythropoietin and a carrier.
REFERENCES:
patent: 5107032 (1992-04-01), Erb et al.
Omar Farooq (1994) "Oxidation of Aromatic 1,2-Dimethanols by Activated Dimethyl Sulfoxide," Synthesis, pp. 1035-1036 (Exhibit 3).
Whitehouse M. W. and Leader J. E. (1966) "Biochemical Properties of Anti-Inflammatory Drugs-IX," Biochemical Pharmacologyvol. 16, pp. 537-551 (Exhibit 4).
Billington David Charles
Collington Eric W.
Golding Bernard T.
Houck David R.
Kitchin John
OSI Pharmaceuticals, Inc.
Richter Johann
Solola Taofiq A.
White John P.
LandOfFree
Tetracyclic compounds for enhancing biosynthesis of erythropoiet does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Tetracyclic compounds for enhancing biosynthesis of erythropoiet, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tetracyclic compounds for enhancing biosynthesis of erythropoiet will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1325288