Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-11-10
1997-01-28
Wu, Shean C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514287, 546 62, 546 64, 546 65, 546 70, 546 77, 546 78, A01N 4390, C07D47100, C07D48700, C07D49800
Patent
active
055978320
ABSTRACT:
A tetracyclic compound of the formula: ##STR1## wherein A and the atoms to which it is attached and the optional double bond represent a mono- or di-heterocyclic ring selected from: ##STR2## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and X are specifically defined, which compounds are useful in the treatment of dopamine-related neurological, psychological and cardiovascular disorders as well as in the treatment of substance abuse and other addictive behavior disorders, cognitive impairment and attention deficit disorder.
REFERENCES:
patent: 2691024 (1954-10-01), Horlein et al.
patent: 3541100 (1970-11-01), Ramirez et al.
patent: 3830647 (1974-08-01), Janssens et al.
patent: 3832171 (1974-08-01), Janssens et al.
patent: 3943137 (1976-03-01), Higuchi et al.
patent: 4145434 (1979-03-01), Van DeBerg
patent: 4282227 (1981-08-01), Brenner
patent: 4340600 (1982-07-01), Brenner et al.
patent: 5047536 (1991-09-01), Nichols
Katerinopoulos, et al., "Structure-Activity Relationships for Dopamine Analogs: A Review", in Drugs of the Future, vol. 12, pp. 223-253, 1987.
Anderson, et al., "Thienopyridine Derivatives Identified as the First Selective, Full Efficacy, Dopamine D1 Receptor Agonists", European Journal of Pharmacology, 13 pp. 291-292, 1987.
Kiguchi, et al., "A Route for Total Synthesis of Ergot Alkaloids Synthesis of the Despyrrole Analogs of Methyl Lysergate, Isolysergol, and isofumigaclavine A" Heterocycles, 19, pp. 1873-1877, 1982.
Kaiser, et al., "Dopamine Receptors: Functions, Subtypes and Emerging Concepts", in Medicinal Research Reviews, vol. 5, pp. 145-229, 1985.
Wei and Teitel, "Synthesis of a Benzo[a]Phenanthridine Isomeric with Apomorphine" Heterocycles, 8 p. 97, 1977.
Brewster, et al., "Trans-10, 11,Dihydroxy-5,6,61,7,8,12b-Hexahydrobenzo[a]Phenanthridine: A Highly Potent Selective Dopamine D.sub.1 Full Agonists", Journal of Medicinal Chemistry, 33, pp. 1756-1764, 1990.
Hong Yufeng
Michaelides Michael R.
Abbott Laboratories
Browder Monte R.
Wu Shean C.
LandOfFree
Tetracyclic compounds as dopamine agonists does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Tetracyclic compounds as dopamine agonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tetracyclic compounds as dopamine agonists will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-941712