Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-09-25
2008-12-30
Habte, Kahsay T (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S099000
Reexamination Certificate
active
07470683
ABSTRACT:
Compounds of formula I, of trans relative configuration:wherein:X represents an oxygen atom or an NR2group,Y represents a group selected from —CH2—, —(CH2)2— and —CH═CH—,R1and R2, which may be the same or different, each represents a hydrogen atom or a group selected from alkyl, cycloalkyl and cycloalkylalkyl,in racemic form or in the form of optical isomers,and also addition salts thereof with a pharmaceutically acceptable acid, and hydrates thereof.Medicinal products containing the same which are useful in the treatment of disorders of the central nervous system that involve the dopaminergic system.
REFERENCES:
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Peglion, et al., “Tetracyclic analogs of [+]-S 14297: synthesis and determination of affinity and selectivity at cloned human dopamine D3 vs. D2 receptors” Bioorganic & Mecidinal Chemistry Letters, 7(7), 881-886, 1997.
French Preliminary Search Report for FR0608413 of Apr. 18, 2007.
Brocco Mauricette
Millan Mark
Peglion Jean-Louis
Poitevin Christophe
Habte Kahsay T
Hueschen and Sage
Les Laboratoires Servier
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