Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Allergen or component thereof
Patent
1975-08-26
1977-05-17
Jaisle, Cecilia M. S.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Allergen or component thereof
260562A, 260574, 260607A, 260609R, 260621R, 260622R, 260623R, 424257, 424283, 260279R, 260289R, 2603067R, 260307A, 260328, 260335, 260327TH, 2603452, 260515A, 260515M, 260515P, 260516, 260518A, 260518R, 260519, 260521N, 260521P, 260521R, 260521S, C07D33516
Patent
active
040242722
ABSTRACT:
Tetracyclic compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each are H or alkyl, R.sup.5 is H, F, Cl, Br, CF.sub.3, OH, alkyl, alkoxy, NO.sub.2, NH.sub.2, alkylamino, dialkylamino or acylamino and X is O, S, SO, SO.sub.2, NH, N-alkyl or N-acyl, alkyl and alkoxy in each case being of 1-3 carbon atoms and acyl in each case being of 1-4 carbon atoms, with the proviso that when R.sup.5 is methoxy and X is a sulfur atom, R.sup.5 is in the 8- or 9-position only, and their physiologically acceptable acid addition salts, possess broad spectrum antibacterial activity, including tetracycline-resistant Gram-positive and Gram-negative organisms.
REFERENCES:
patent: 3988468 (1976-10-01), Rogalski et al.
Bergmann Rolf
Gante Joachim
Gottschlich Rudolf
Kirchlechner Richard
Rogalski Werner
Jaisle Cecilia M. S.
Merck Patent Gesellschaft mit beschrankter Haftung
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