Tetracyclic benzamide derivatives and methods of use thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C544S125000, C546S061000, C514S284000

Reexamination Certificate

active

10788228

ABSTRACT:
The invention relates to Tetracyclic Benzamide Derivatives; compositions comprising a Tetracyclic Benzamide Derivative; and methods for treating or preventing an inflammatory disease, a reperfusion disease, an ischemic condition, renal failure, diabetes, a diabetic complication, a vascular disease, or cancer, comprising administering to a subject in need thereof an effective amount of a Tetracyclic Benzamide Derivative.

REFERENCES:
patent: 3710795 (1973-01-01), Higuchi et al.
patent: 4113731 (1978-09-01), Winters et al.
patent: 4263304 (1981-04-01), Ishizumi et al.
patent: 4623304 (1986-11-01), Chikada
patent: 5079246 (1992-01-01), Forbes et al.
patent: 5260316 (1993-11-01), Van Duzer et al.
patent: 5262564 (1993-11-01), Kun et al.
patent: 5597831 (1997-01-01), Michalsky et al.
patent: 5710162 (1998-01-01), Okazaki et al.
patent: 5733918 (1998-03-01), Okazaki et al.
patent: 6028079 (2000-02-01), Okazaki et al.
patent: 6346535 (2002-02-01), Cotter et al.
patent: 6346536 (2002-02-01), Li et al.
patent: 6498194 (2002-12-01), Cotter et al.
patent: 6635642 (2003-10-01), Jackson et al.
patent: 6828319 (2004-12-01), Jagtap et al.
patent: 2002/0099063 (2002-07-01), Cotter et al.
patent: 2004/0039009 (2004-02-01), Jagtap et al.
patent: 2005/0261288 (2005-11-01), Jagtap et al.
patent: 2006/0019980 (2006-01-01), Szabo et al.
patent: 2349227 (2000-05-01), None
patent: 2025932 (1980-01-01), None
patent: 2003267888 (2003-09-01), None
patent: WO 93/05023 (1993-03-01), None
patent: WO 99/08680 (1999-02-01), None
patent: WO 99/11311 (1999-03-01), None
patent: WO 99/11623 (1999-03-01), None
patent: WO 99/11628 (1999-03-01), None
patent: WO 99/11644 (1999-03-01), None
patent: WO 99/11645 (1999-03-01), None
patent: WO 99/11649 (1999-03-01), None
patent: WO 99/59973 (1999-11-01), None
patent: WO 99/59975 (1999-11-01), None
patent: WO 00/21537 (2000-04-01), None
patent: WO 00/39070 (2000-07-01), None
patent: WO 00/39104 (2000-07-01), None
patent: WO 00/42040 (2000-07-01), None
patent: WO 01/12199 (2001-02-01), None
patent: WO-01/90077 (2001-11-01), None
patent: WO 02/06284 (2002-01-01), None
patent: WO-04/014862 (2004-02-01), None
patent: WO 2004/043959 (2004-05-01), None
patent: WO 2005/012524 (2005-02-01), None
patent: WO 2005/053662 (2005-06-01), None
Abdelkarim et al., Protective effects of PJ34, a novel, potent inibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke, Int. J. Mol. Med., 7:255-260, 2001.
Aldrich, p. 32, Aldrich Chemicl Company, 1992.
Ando et al., Cyclization reactions of 1,2-bis(2-cyanophenyl—propionitriles. II. Synthesis of 5-amino-4,7-dimethoxy-11H-indo[1,2-c]isoquinolin-11-one, Bull. Chem. Soc. Japan, 47:1014-17, 1974.
Bloch et al., The role of the 5′-hydroxyl group of adenosine in determining substrate specificity for adenosine deaminase, J. Med. Chem., 10(5):908-912, 1967.
Burger's Medicinal Chemistry and Drug Discovery, 5thed., vol. 1: Principles and Practice, John Wiley and Sons, Inc., pp. 975-977, 1994.
Chatterjea et al., Cyclisation of alpha-benzythomophthalic acids, Experientia, 16:439-440, 1960.
Cushman et al., Synthesis of new indeno[1,2b]isoquinolines: Cytotoxic non-camptothecin topoisomerase I inhibitors, J. Med. Chem., 43(20):3688-3698, 2000.
Dusemund et al., 5-hydroxyisoindolo[2,1b]isoquinolin-7-one: Synthesis and isomerization, Arch. Pharm (Weinheim, Ger.), 317:381-2, 1984.
Grupp et al., Protection against hypoxia-reoxygenation in the absence of poly9ADP-ribose) synthetase in isolated working hearts, J. Mol. Cell Cardiol., 31:297-303, 1999.
Hakimelahi et al., Ring Open Analogues of Adenine Nucleoside, Aminoacyl Derivatives of Cyclo- and Acyclo-nucleosides, Helvetica Chemica Acta, 70:219-231, 1987.
Hiremath et al., A New Method for the Synthesis of 6H, 11H-Indolo[3,2-c]-isoquinolin-5-ones/thiones and their Reactions, J. Heterocyc. Chem., 30(3):603-609, 1993.
Hiremath et al., Synthesis of substituted 2-(5-oxo/thioxo-1,3,4-oxadiazol-2-yl)-indoles & 2-(5-oxo/thioxo-1,3,4-oxadiazol-2-ylamino)indoles, Indian Journal of Chemistry, Section B 22B(6):571-576, 1983.
Jantzen and Robinson, Modern Pharmaceutics, 3rded., eds. Baker and Rhodes, p. 596, 1995.
Kawana et al., Nucleoside Peptides. III. The Synthesis of N-[1-(9-Adenyl)-β-D-ribofuranuronosyl] Derivatives of Certain Aminio Acids and Peptides, J. Org. Chem., 37(2):288-290, 1972.
Kirby et al., Hydride hyperconjugation in 1(3)-methylazulenes, Tetrahedron Lett., 27:1-4; 1960.
Kirby et al., 4,6,8-trimethylazulenium percholrate. Chemistry & Industry (London, UK), 1217-1218, 1960.
Lal et al., Applications of carbon-nitrogen bond cleavage reaction: A synthesis/derivisation of 11H-indeno[1,2-c]isoquinolones, Indian J. Chem., Sect. B, 38B:33-39, 1999.
Lamping et al., LPS—binding protein protects mice from septic shock caused by LPS or gram-negative bacteria, J. Clin. Invest., 101(10):2065-2071, 1998.
Mabley et al., Inhibition of poly(ADP-ribose) synthetase by gene disruption or inhibitin with 5-iodo-6-amino-1,2-benzopyrone protects mice from multiple-low-dose-streptozotocin-induced diabetes, Br. J. Pharmacol., 133(6):909-919, 2001.
Mandir et al., A novel in vivo post-translational modification of p53 by PARP-1 in MPTP-induced parkinsonism, J. Neurochem., 83(1):186-192, 2002.
Mandir et al., Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism, Proc. Natl. Acad. Sci. U.S. A., 96(10):5774-5779, 1999.
Morrison and Boyd, Organic Chemistry, 5thed., Allyn and Bacon, Inc., p. 179, 1987.
Ojika et al, Ptaquiloside, a Potent Carcinogen Isolated From Bracken Fern Pteridium Aquilinum Var. Latiusculum: Structure Elucidation Based On Chemical and Spectral Evidence, and Reactions with Amino Acids, Nucleosides, and Nucleotides, Tetrahedron, 43(22):5261-5274, 1987.
Parrillo, Pathogenic mechanisms of septic shock, N. Eng. J. Med., 328:1471-1477, 1993.
Southan and Szabo, Poly(ADP-ribose) polymerase inhibitors, Curr. Med. Chem., 10:321, 2003.
Strumberg et al., Synthesis of cytotoxic indenosoquinoline topolsomerase I poisons, J. Med. Chem., 42(3):446-457, 1999.
Virag et al., Peroxynitrite-induced thymocyte apoptosis: the role of caspases and poly(ADP-ribose) synthetase (PARP) activation, immunol., 94(3):345-355, 1998.
Wang et al., Apoptosis inducing factor and PARP-mediated injury in the MPTP mouse model of Parkinson's disease, Ann N.Y. Acad. Sci., 991:132-139, 2003.
Wawzonek et al., Synthesis of 6-substituted-6H-indeno[1,2-c]isoquinoline-5,11-diones, Org. Prep. Proc. Int., 14:163-8, 1982.
Wawzonek et al., Preparation and reactions of 4b-acetoxy-4b,9b-dihydroindeno[2,1-a]indene-5,10-dione, Can. J. Chem., 59:2833, 1981.
Yamaguchi et al., The Synthesis of Benzofuroquinolines. IX. A Benzofuroisoquinolinone and a Benzofuroisocoumarin, J. Heterocycl. Chem., 32(2):419-423, 1995.
Yamaguchi et al., The synthesis of benzofuroquinolines. X. Some benzofuro[3,2-c]isoquinoline derivatives, J. Hetercycl. Chem., 32(5):1517-1520, 1995.
Banasik et al., Inhibitors and activators of ADP-ribosylation reactions. Mol Cell Biochem. Sep. 1994;138(1-2):185-97.
Banasik et al., Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase. J Biol Chem. Jan. 25, 1992;267(3):1569-75.
Chatterjea et al., On 4-Keto-3:4-Dihydroisocoumarin, J. Indian Chem. Society, 44(11):911-919, 1967.
Griffin et al., Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). J Med Chem. Dec. 17, 1998;41(26):5247-56.
Hiremath et al., 1997, “Synthesis and Biological Studies of Some New Bridgehead Nitrogen Heterocycles Containing Indoloisoquinoline Nucleus”, Oriental J. of Chemistry 13 (2):173-6.
Hiremath et al., Synthesis of Substituted 7H-Indolo[2,3-c] isoquinolines, Indian J. Of Chemistry, Section B 24B(12):1235-1238, 1985.
Hiremath et al., Synthesis and Biological Evaluation of Some Substituted 5H, 6H, 7H,-Indolo[2,3-C] Isoquinolin-5-thiones and their Derivatives, Indian J. of Heterocyclic Chemistry, 3(1):37-42, 1993.
Hiremath et

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