Tetracyclic antibiotics and processes for their preparation

Details Tetracyclic antibiotics and processes for their preparation Tetracyclic antibiotics and processes for their preparation

1992-05-28

1995-04-11

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540302, C07D47700, A61K 3140

Patent

active

054058449

ABSTRACT:
Tetracyclic antibiotics and processes for their preparation .beta.-Lactam antibiotics of the formula I, and their pharmaceutically tolerable salts ##STR1## where X is (CH.sub.2).sub.0-2, CR(a)R(b), O, SO.sub.0-2 or NR(c),

REFERENCES:
patent: 4772683 (1988-09-01), Martel et al.
patent: 4841042 (1989-06-01), Habich et al.
patent: 4841043 (1989-06-01), Deziel et al.
R. N. Guthikonda, "Structure-Activity Relationships in the 2-Arylcarbapenem Series: Synthesis of 1-Methyl-2-arylcarbapenems", J. Med. Chem. 1987, 30, 871-880.
R. Deziel et al., "Synthesis of 1-62-Methylcarbapenem Key Intermediate Involving the Labile Acyl Auxiliary 4,4-dimethyl-1, 3-oxazolidine-2-thione", Tetrahedron Letters, vol. 30 (11) : 1345-1348 (1989).

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