Tetracyclic amines useful as cerebrovascular agents

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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540581, 546 75, 549265, 558426, 560 28, 564339, 564171, 568327, C07D20958, C07D22128, C07D22314

Patent

active

051091364

ABSTRACT:
A novel series of tetracyclic amines, methods of preparation, compositions containing the amines, and methods for using them in the treatment and/or prevention of cerebrovascular disorders are disclosed.

REFERENCES:
patent: 4202980 (1980-05-01), Hartenstein et al.
patent: 4376779 (1983-03-01), Belanger et al.
T. A. Lyle et al., "Structure and Activity of Hydrogenated Derivatives of (+)-5-Methyl-10,11-Dihydro-5H-Dibenzo[a,d]cyclohepten-5,10-imine (MK-801)," J. Med. Chem., 1990, 33, pp. 1047-1052.
W. J. Thompson et al., "Synthesis and Pharmacological Evaluation of a Series of Dibenzo[a,d]cycloalkenimines as N-Methyl-D-Aspartate Antagonists", J. Med. Chem., 1990, 33, pp. 789-808.

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