Tetra-, penta-, hexa- and heptapeptides having...

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues

Reexamination Certificate

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Reexamination Certificate

active

10283549

ABSTRACT:
Compounds of formula (SEQ ID NO:2) and (SEQ ID NO:3), which are useful for treating conditions that arise from or are exacerbated by angiogenesis, are described. Also disclosed are pharmaceutical compositions comprising these compounds, methods of treatment using these compounds, and methods of inhibiting angiogenesis.

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patent: 01/38397 (2001-05-01), None
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Bagley, et al., Endothelial Precursor Cells As a Model of Tumor Endothelium : Characterization and Comparison with Mature Endothelial Cells, Cancer Research, Sep. 15, 2003, vol. 63, pp. 5866-5873.
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Flouret et al. “Effects of D-amino acid substituents on degradation of LHRH analogoues by proximal tubule.” Am. J. Physiol. 1987, 252, E320-E326.
Yang et al. “Characterization of proteolytic activites of pulmonary alveolar epithelium.” Int. J. Pharm. 2000, 195, 93-101.
Hagedom & Bikfalvi “Target molecules for anti-angiogenic therapy: from basic research to clinical trials.” Crit. Rev. Onc./Hemat., 2000, 34, 89-110.

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