Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1996-01-04
1999-03-09
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530331, A61K 3800, C07K 523
Patent
active
058800972
ABSTRACT:
Compounds wherein a biologically active molecule is coupled to a glutathione analog through a conjugated system which permits activation of the biologically active molecule while retaining the biologically active molecule tethered to the glutathione analog are useful as tethered prodrugs that slow the rate of clearance of an active biomolecule through the multidrug resistance pump.
REFERENCES:
patent: 5545621 (1996-08-01), Kauvar et al.
patent: 5556942 (1996-09-01), Kauvar et al.
Jedlitschky, G. et al., "ATP-dependent Transport of Glutathione S-Conjugates by the Multidrug Resistance-associated Protein," Cancer Research 54, 4833-4836 (Sep. 15, 1994).
Lyttle, M.H. et al., "Glutathione-S-transferase Activities Novel Aklylating Agents," J. Med. Chem. (1994) 37:1501-1507.
Fenselau, C. et al., "High-performance tandem mass spectrometry in metabolism studies," Xenobiotica (1992) 22(9/10):1207-1219.
Sharer, J. E. et al., "Formation, Stability, and Rearrangements of the Glutathione Conjugates of Butadiene Monoxide: Evidence for the Formation of Stable Sulfurane Intermediates," Chem. Res. Toxicol. (1991) 4(4):430-436.
Akerboom, Th.P.M., et al., "Low- and high-Km transport of dinitrophenyl glutathione in inside of vesicles from human erythrocytes," Biochem Biophys Acta (1992) 1103(1):115-119.
Satiam, A., et al., "Design, Synthesis and Evaluation of Latent Alkylating Agents Activated by Glutathione S-Transferase," (1996) 39:1796-1747.
Bundgaard, H. "Design of Prodrugs" (1985) Elsevier Science Publishers B.V. pp. 1-24.
Silverman, R.B. "The Organic Chemistry of Drug Design and Drug Action" (Academic Press Inc. 1988) pp. 352-401.
Kauvar Lawrence M.
Lyttle Matthew H.
Celsa Bennett
Terrapin Techologies, Inc.
Tsang Cecilia J.
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