Chemistry: analytical and immunological testing – Metal or metal containing – Present in biological fluids
Reexamination Certificate
2007-10-16
2007-10-16
Siew, Jeffrey (Department: 1645)
Chemistry: analytical and immunological testing
Metal or metal containing
Present in biological fluids
C436S017000, C436S063000
Reexamination Certificate
active
10414469
ABSTRACT:
The present invention relates to rapid methods for the detection of ischemic states and to kits for use in such methods. Provided for is a rapid method of testing for and quantifying ischemia based upon methods of detecting and quantifying the existence of an alteration of the serum protein albumin which occurs following an ischemic event; methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of circulating albumin, analysis and measurement of the ability of serum albumin to bind exogenous cobalt, detection and measurement of the presence of endogenous copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following an ischemic event. Also taught by the present invention is the detection and measurement of an ischemic event by measuring albumin N-terminal derivatives that arise following an ischemic event, including truncated albumin species lacking one to four N-terminal amino acids or albumin with an acetylated N-terminal Asp residue.
REFERENCES:
patent: 3955926 (1976-05-01), Fischer
patent: 4230601 (1980-10-01), Hill
patent: 4337064 (1982-06-01), Gindler
patent: 4379848 (1983-04-01), Yeaw
patent: 4434234 (1984-02-01), Adams et al.
patent: 4468466 (1984-08-01), Morrissey
patent: 4486282 (1984-12-01), Bier
patent: 4492753 (1985-01-01), Shell et al.
patent: 4510383 (1985-04-01), Ruppender
patent: 4568647 (1986-02-01), Sanford
patent: 4569794 (1986-02-01), Smith et al.
patent: 4592893 (1986-06-01), Poppe et al.
patent: 4713327 (1987-12-01), Findlay et al.
patent: 4786605 (1988-11-01), Mauck et al.
patent: 4960710 (1990-10-01), Lau
patent: 5077222 (1991-12-01), Lau
patent: 5141855 (1992-08-01), Schmittou
patent: 5169936 (1992-12-01), Staples et al.
patent: 5173422 (1992-12-01), Knowles et al.
patent: 5173431 (1992-12-01), Pugia et al.
patent: 5182214 (1993-01-01), Kessler et al.
patent: 5183809 (1993-02-01), Weisz et al.
patent: 5223392 (1993-06-01), Cohen et al.
patent: 5225354 (1993-07-01), Knowles et al.
patent: 5227307 (1993-07-01), Bar-Or et al.
patent: 5246835 (1993-09-01), Suzuki et al.
patent: 5290519 (1994-03-01), Bar-Or et al.
patent: 5290678 (1994-03-01), Jackowski
patent: 5326707 (1994-07-01), Franke et al.
patent: 5503987 (1996-04-01), Wagner et al.
patent: 5532136 (1996-07-01), Carlson et al.
patent: 5569608 (1996-10-01), Sommer
patent: 5604105 (1997-02-01), Jackowski
patent: 5620856 (1997-04-01), Carlson et al.
patent: 5639624 (1997-06-01), Wagner et al.
patent: 5654160 (1997-08-01), Johnson
patent: 5656729 (1997-08-01), Fuluhata et al.
patent: 5670627 (1997-09-01), Johnson
patent: 5670645 (1997-09-01), Johnson
patent: 5683907 (1997-11-01), Johnson
patent: 5710008 (1998-01-01), Jackowski
patent: 5744358 (1998-04-01), Jackowski
patent: 5747274 (1998-05-01), Jackowski
patent: 5804452 (1998-09-01), Pronovost et al.
patent: 5876969 (1999-03-01), Fleer et al.
patent: 5994339 (1999-11-01), Crapo et al.
patent: 6020204 (2000-02-01), DerVartanian et al.
patent: 6083758 (2000-07-01), Imperiali et al.
patent: 6087184 (2000-07-01), Magginetti et al.
patent: 6171870 (2001-01-01), Freitag
patent: 6235489 (2001-05-01), Jackowski
patent: 6268223 (2001-07-01), Cornell-Bell et al.
patent: 6274305 (2001-08-01), Sonnenschein et al.
patent: 6335205 (2002-01-01), Bausback
patent: 6375930 (2002-04-01), Young et al.
patent: 6410341 (2002-06-01), Freitag
patent: 6444432 (2002-09-01), Kleinfeld
patent: 6461875 (2002-10-01), Bar-Or et al.
patent: 6475743 (2002-11-01), Bar-Or et al.
patent: 6492179 (2002-12-01), Bar-Or et al.
patent: 6767708 (2004-07-01), Williams et al.
patent: 2003/0194813 (2003-10-01), Bar-Or et al.
patent: 2003/0215359 (2003-11-01), Bar-Or et al.
patent: 2004/0175754 (2004-09-01), Bar-Or et al.
patent: 2004/0209379 (2004-10-01), Bar-Or et al.
patent: 2005/0142613 (2005-06-01), Bar-Or et al.
patent: WO 00/20454 (2000-04-01), None
patent: WO00/20454 (2000-04-01), None
patent: WO00/52476 (2000-09-01), None
Sadler et al. , European Journal of Biochemistry, vol. 220, No. 1, pp. 193-200, Feb. 1994.
Veien et al. ,Contact Dermatitis vol. 5, pp. 378-382, 1979.
Reimer and Jennings (1992) The Heart and Cardiovascular System, Second Edition, Chapter 75, pp. 1875-1951 H.A. Fozzard et al., ed. Raven Press, Ltd., New York.
Ishikawa et al (1997) Clinical Chemistry 43:467-475.
Roberts (1997) Clinics in Laboratory Medicine 17:669-683.
Göbel et al (1998) European Heart Journal 19:1208-1213.
Pepine et al. (1994) Circulation 90:762-768.
Hedges et al. (1996) Acad. Emerge. Med. 3:27-33.
Masuoka et al. (1993) The Journal of Biological Chemistry 268:21533-21537.
McCord (1985) The New England Journal of Medicine 312:159-163.
Kadota et al. (1990) Japanese Circulation Journal 55:937-941.
DNA Damage Linked to Risk of Breast Cancer Spread, found at http://www.pslgroup.com/dg/6c2d.htm (1996).
Davies (1987) The Journal of Biological Chemistry 262:9895-9901.
Davies and Goldbert (1987) The Journal of Biological Chemistry 262:8220-8226
Ishimoto et al. (1996) Role of Oxygen-Derived Free Radicals in Fetal Growth Retardation Induced by Ischemia-Referfusion in Rats, APStracts 3:0371H found at http://oac3.hsc.uth.tmc.edu/apstracts/1996/heart/September/371h.html.
Vogel, The Zinc Group (Group IIIB), pp. 198-202.
Alberts et al., Molecular Biology of the Cell, Second Edition, Garland Publishing, Inc., (1989), pp. 174-180.
Stryer, Biochemistry, Third Edition, W.H. Freeman and Co, (1988), pp. 62-64 and 895-897.
Braughler (1987) Calcium and Lipid Peroxidatio, from Central Nervous System Diseases Research Unit, p. 99, The Upjohn Company, Kalamazoo, Michigan.
Halliwell (1987) Proceedings of a Brook Lodge Spymposium, August Michigan, Apr. 27-29, 1987.
Hisashi et al (1997) Atp-Sensitivie K+ Channels in Pancreatic, Cardiac, and Vascular Smooth Muscle Cells, APStracts 4:0291C found at http://oac.3.hsc.usth.tmc.edu/apstracts/1997/cell/October/291C.html.
Afanas'Ev, Superoxide Ion: Chemistry and Biological Implications, vol. I, pp. 26, 51, 147, 168-196, 248-266 (CRC Press, Boca Raton, FL) (1989).
Brennan et al. (1988) Clinica Chimica Acta 176(2):179-184.
Davies et al. (1987) J. Biol. Chem. 262(20):9902-9907.
Davies et al. (1987) J. Biol. Chem. 262(20):9914-20.
Pepine et al. (1994) J. Myocardial Ishemia 6/3(8-9).
Peters, Theodore Jr., (1996) All About Albumin Biochemistry, Genetics, and Medical Applications, Academic Press p. 214.
Tucker, “Involvement of a Lysine Residue in the N-terminal Ni2+ and Cu2+ Binding Site of Serum Albumins, Comparison with Co2+, Cd2+ and A13+,” found at http://search19.proxy.aol.com:8000/post-query/MedLine/hrs1994/23450?albumin+n+t p. 1 (1994), Christopher Ingold Laboratories, University of London, England.
Fleming and Nixon, (1986) Analytical Biochemistry 154(2):691-701.
Yoon et al. (1989) J. Surgical Res. 46:163-165
Karck et al. (1992) Transplantation 11:979-985.
Laussac and Sarkar (1984) Biochemistry 23:2832-2838.
Cotelle et al. (1992) J. Inorganic Biochemistry 46:7-15.
Keller et al. (1993) Chem. Res. Toxicol. 6:430-433.
Harlow et al., Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory,Chapter 6, pp. 139-243.
Harlow et al., Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory, Chapter 14, pp. 553-612.
Anderson et al (1995) Effects of na+k-2cl Contrasport Inhibition on Myocardial NA and CA During Ischemia and Referfusion, found at http://www.uth.tmc.edu/aspstracts/1995/cell/september319c.html, p. 1, published in APStracts on Sep. 23, 1995.
Chan et al. (1995) Eur. J. Biochem. 227:524-528.
Davies (1986) Journal of Free Radicals in Biology & Medicine 2:155-161 and pp. 164-169.
Gomez et al (1996) Clinician Reviews 6:148 or J. Am. Coll. Cardiol. 28:25-33.
Halliwell (1988) Biochemical Pharmacology 37:569-571.
Halliwell and Gutteridge (1990) Archives of Biochemistry and Biophysics 280:1-8.
Halliwell and Gutteridge (1986) Archives of Biochemistry and Biophysics 246:501-514.
Hayakawa et al. (1997) Journal of Chromatography 698:27-33.
Huang et al. (1995) Ischemia- and Reperfusion-Sensitive Cardiac Sympathetic Afferents: Influe
Bar-Or David
Lau Edward
Winkler James V
Ischemia Technologies, Inc.
Shahnan-Shah Khatol S.
Siew Jeffrey
Swanson & Bratschun L.L.C.
LandOfFree
Tests for the rapid evaluation of ischemic states and kits does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Tests for the rapid evaluation of ischemic states and kits, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tests for the rapid evaluation of ischemic states and kits will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3849014