Testosterone derivatives and assay method

Details Testosterone derivatives and assay method Testosterone derivatives and assay method

1977-09-27

1980-04-08

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

260112B, 26023955C, 2603971, 424 12, G01N 3316, A61K 4300, C07D47100, C07J 4100

Patent

active

041972864

ABSTRACT:
An anti-testosterone serum is provided which is highly selective to the measurement of testosterone using radioimmunossay techniques in both male and female plasma without resorting to chromatography even though the plasma may have a high 5.alpha.-dihydrotestosterone content. In addition, the high progesterone concentration normally present in female plasma has no effect on the assay of this plasma. The preferred hapten for producing the serum is 17.beta., 19-dihydroxyandrost-4-en-3-one 19-carboxymethyl ether although related compounds as disclosed herein are also useful.

REFERENCES:
patent: 4031117 (1977-06-01), Rao
patent: 4085202 (1978-04-01), Rao
Ed. Gupta, Radio Immuno Assay of Steroid Hormones, Verlag Chemie, Weinheim, 1975, pp. 84-90.

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