Testosterone derivative

Details Testosterone derivative Testosterone derivative

2006-01-24

2006-01-24

Qazi, Sabiha (Department: 1616)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

C514S182000, C552S642000, C552S644000, C552S645000, C552S649000, C424S001110

Reexamination Certificate

active

06989378

ABSTRACT:
The invention is the novel androgen (7α,17β)-7-methyl-17-[(1-oxoundecyl)oxy]estr-4en-3one (MENT undecanoate). This compound distinguishes favourably from other testosterone derivatives in that it has a good solubility in oily media. It particularly exhibits a good dissolved potency relative to testosterone. The compound is particularly suitable for administration by means of injection.

REFERENCES:
patent: 5342834 (1994-08-01), Bardin et al.
Kamischke et al, Intramuscular Testosterone Undecanoate and Norethisterone Enanthate in a Clinical Trial for Male Contraception, The Journal of Clinical Endocrinology & Metabolism, vol. 86, No. 1, 303-309, 2000.
Kamischke et al, An Effective Hormonal Male Contraceptive Using Testosterone Undecanoate with Oral or Injectable Norethisterene Preperations, J Clin Endocrinol Metab 87(2): 530-539, 2002.
Abstract of Grimes et al, Steroid Hormones For Contraception in Men, Cochrane Database Syst Rev. 2004; (3): CD004316.
Chaudry, M., et al: “Hansch analysis of the anabolic activities of some nandrolone esters” Journal of medical Chemistry, vol. 17, No. 2, Feb. 1974.
Kumar, N. et al:“Pharmacokinetics of 7 alpha-methyl-19-nortestosterone in men and cynomolgus monkeys” Chemical Abstracts, vol. 127, No. 18, Nov. 3, 1997.
Zhang, Y. et al: “Pharmacological studies of testosterone undecanoate, a new long-acting androgen preparation” Chemical Abstract, vol. 104 No. 9, Mar. 3, 1986.
Davidson, D. et al.: “Increasing testosterone undecanoate in eugonadal men” Chemical Abstract, vol. 107, No. 13, Sep. 28, 1987.
Bremner, William J. et al: (DN 134:80878, CAPLUS, abstract of Int. Congr. Ser. (2000), 1206 (Current Knowledge in Reproductive Medicine), 315-331).

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