Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1976-06-23
1978-05-09
Roberts, Elbert L.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
2603971, 2603972, 2603974, 26023955C, C07J 900, A61K 3156
Patent
active
040887600
ABSTRACT:
Compounds of the following general formula are testosterone 5.alpha.-reductase inhibitors rendering said compounds useful in the treatment of acne and oily skin: ##STR1## wherein n is an integer of from 0 to 4; R.sub.1 is --COOR.sub.2, --CONR.sub.3 R.sub.4, --CHO or --CH.sub.2 OR.sub.5 ; R.sub.2 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, or benzyl; each of R.sub.3 and R.sub.4 is hydrogen or a straight or branched lower alkyl group of from 1 to 4 carbon atoms; and R.sub.5 is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 20 carbon atoms and is straight or branched, benzoyl, phenylalkylcarbonyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched, or cycloalkylcarbonyl wherein the cycloalkyl moiety has from 5 to 10 carbon atoms.
REFERENCES:
patent: 3153615 (1964-10-01), Bosshardt et al.
patent: 3535312 (1970-10-01), Philippson et al.
patent: 3560558 (1971-02-01), Hayakawa et al.
patent: 3917829 (1975-11-01), Voight et al.
Chemical Abstracts, vol. 70, (1969), Pars. 88,067(f).
Chemical Abstracts, vol. 74, (1971), Pars. 29,155(t).
Benson Harvey D.
Blohm Thomas R.
Hattan L. Ruth
Rauchfuss, Jr. George W.
Retter Eugene O.
Richardson-Merrell Inc.
Roberts Elbert L.
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