Testing the integrity of liquid containing hermetically sealed c

Details Testing the integrity of liquid containing hermetically sealed c Testing the integrity of liquid containing hermetically sealed c

1979-08-14

1981-05-12

Dixon, Harold A.

Radiant energy

Radiation tracer methods

Radioactive tracer methods

250302, G01T 1161, G09K 300

Patent

active

042674492

ABSTRACT:
A method for detecting leaky ampules filled with a liquid such as a parenteral solution. The ampules to be tested are immersed in a solution containing a short-lived radionuclide, and a pressure differential is imposed between the solution containing the radionuclide and the parenteral solution or other liquid contained in the ampules. The ampules are then removed from solution, decontaminated to remove any solution adhering to the outer surface and pores thereof, dried, and finally examined for electromagnetic radiation, preferably gamma radiation, emanating from the interior of the ampules which would indicate a leaky condition thereof.

REFERENCES:
patent: 3135865 (1964-06-01), Reed et al.
patent: 3247382 (1966-04-01), Schneider et al.
patent: 3649096 (1972-03-01), Clark et al.
"Study . . . Detecting Leaks-Ampuls" by Artz et al., Jour. of Pharmaceutical Sciences, vol. 50, No. 3, pp. 258-262.

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