Chemistry: analytical and immunological testing – Cancer
Patent
1982-02-05
1984-04-24
Turk, Arnold
Chemistry: analytical and immunological testing
Cancer
436 86, 436 89, G01N 3368
Patent
active
044448902
ABSTRACT:
Antineoplastons are termed a group of plasma, tissue and urinary peptides and amino acid derivatives capable of modulating abnormal tissue growth, such as neoplastic disease. Antineoplastons, when administered to persons with neoplastic disease, have been shown to be effective against several forms of cancer and tumors. A procedure is provided herein for the determination of antineoplaston levels in physiological tissues or fluids, especially plasma and urine. The procedure involves purification of antineoplastons by high performance liquid chromatography on silica gel followed by resolution of antineoplastons by high performance liquid chromatography on sulfonated polystyrene. A quantitative determination of antineoplaston tissue or fluid levels provides valuable data to aid clinical diagnosis of cancer. In addition, the quantitative determination also provides a means for monitoring the efficacy of antineoplastic therapy.
REFERENCES:
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Burzynski, "Antineoplastons: Biochemical Defense Against Cancer", Physiol. Chem. & Physics, 8:275-279 (1976).
Beall et al., "Polypeptides that Inhibit Human Breast Cancer Cell Division", Cancer Biochem. Biophys., 3:93-96(1979).
Burzynski et al., "Antineoplastic Peptides from Urine and Their Inhibition of DNA, RNA, and Their Proteins", No. 183, May 1976, Special Listing of Current Cancer Research on Mechanism of Action of Anticancer Agents.
Sadee et al., Chemical Abstracts, vol. 85, 1976, No. 85:71930u.
Mardasher et al., Soviet Medicine 31(3): 27-30 (Mar. 1978).
Gross et al., Physiol. Chem. & Phys. 8: 161-166 (1976).
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