Test to determine predisposition or susceptibility to DNA associ

Details Test to determine predisposition or susceptibility to DNA associ Test to determine predisposition or susceptibility to DNA associ

1995-04-26

1996-01-09

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 4, 435 15, 435 29, 4351731, 435820, 436501, 436 63, 436 64, 436813, 436815, 514 2, 514 44, 536 221, 536 253, 935 77, C12Q 168, A61K 4800, A61K 4900

Patent

active

054828333

ABSTRACT:
Cellular DNA repair enzyme activity has been found to be an indicator of susceptibility or predisposition of an individual to DNA associated diseases. The activity of the enzyme adenosine diphosphate ribosyl transferase (ADPRT) has been found to be a good indicator as to the susceptibility of an individual to DNA associated diseases, such as cancer.

REFERENCES:
patent: 4585736 (1986-04-01), Dolbeare et al.
Pero et al. (1985) Carcinogenesis, vol. 6, No. 7, pp. 1055-1058.
Pero et al. (1985) Mutation Res., vol. 142, pp. 69-73.
Biological Abstracts 78 (7) 55503.
Biological Abstracts 80 (2) 13747.
Chemical Abstract 105: 19647.
Chemical Abstract 105: 95311.
Davis et al, Microbiology including Immunology and Molecular Genetics, 3rd ed., pp. 186-189 (1980).
Robbins, Pathologic Basis of Disease, pp. 148-152, (1974).
Simic et al, Mechanisms of DNA Damage and Repair, pp. 164-165 and 357-363, (1986).
Weisburger, J. "Bioassays and Tests for Chemical Carcinogens," Chemical Carcinogens, 1976, chapter 1, pp. 1-23.

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