Test sample container

Details Test sample container Test sample container

1978-12-18

1981-01-20

Penland, R. B.

Chemistry: molecular biology and microbiology

Apparatus

Bioreactor

435 35, 435296, 435299, 435808, C12M 134

Patent

active

042463521

ABSTRACT:
The present invention provides a test sample container for measuring the biological activity of cells, bacteria, or micro-organisms in a test sample by radiometric techniques. The container is suited for use with automated laboratory equipment and provides greatly improved measurement efficiency over prior designs. In one embodiment, the test sample container includes a serum vial adapted to contain a quantity of a test sample and a radionuclide-labeled nutrient media. A micro-tube, which contains a mixture of a gas absorber and a scintillation compound, is positioned above the surface of the sample/media mix by a split-skirt stopper that also serves to seal the serum vial. The gas metabolized or otherwise evolved by the micro-organisms in the test sample is absorbed by the absorber in the micro-tube causing the scintillation compound to emit light flashes at a rate proportional to the quantity of radioactive gas absorbed. These light emissions are detected and counted in a conventional scintillation counter and provide a continuous indication of the radiorespirometric profile of the micro-organisms.

REFERENCES:
patent: 3676679 (1972-07-01), Waters
patent: 3819489 (1974-06-01), Kronick
patent: 3844894 (1974-10-01), Kronick
patent: 3941660 (1976-03-01), Mirsky
patent: 3944471 (1976-03-01), Waters
patent: 3997404 (1976-12-01), Waters
patent: 4057470 (1977-11-01), Schrot
Buddemeyer, "Liquid Scintillation Vial for Cumulative & Continuous Radiometric Measurements of in Vitro Metabolism", Applied Microbiology, Aug. 1974, pp. 177-180.

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